Hidradenitis suppurativa, Dowling-Degos and multiple epidermal cysts: a new follicular occlusion triad.

The pathogenesis of hidradenitis suppurativa: a closer look at apocrine and apoeccrine glands.

We undertook a retrospective pathological study of 118 skin resection specimens from 101 patients with hidradenitis suppurativa. Follicular occlusion was identified in all the specimens, regardless of disease duration (1 month to 18 years), but was not noted in the axillary and inguinal skin of controls. We therefore regard follicular occlusion as an early and important feature in the pathogene...

Dermatopathology Cytokeratin expression in pilonidal sinus

Background Pilonidal sinus (PS) is considered to belong in the category of follicular occlusion diseases (acne triad). Objectives The aim of our study was to elucidate the pathogenesis of PS by evaluating its cytokeratin (CK) expression. Methods CK expression in nine cases of PS was studied immunohistochemically using six antikeratin antibodies. Results Infundibular-like epithelium contained CK...

A novel connexin 26 gene mutation associated with features of the keratitis-ichthyosis-deafness syndrome and the follicular occlusion triad.

We report the case of a congenitally deaf white male with mild palmoplantar keratoderma, ichthyosiform scaling, follicular hyperkeratosis, and mild keratitis, features consistent with keratitis-ichthyosis-deafness syndrome. His major problem was severe, disfiguring, inflammatory dissecting folliculitis of the scalp, hidradenitis suppurativa, and cystic acne, features comprising the follicular o...

A case of dissecting cellulitis and a review of the literature.

Dissecting cellulitis (also called perifolliculitis capitis abscedens et suffodiens) manifests with perifollicular pustules, nodules, abscesses and sinuses that evolve into scarring alopecia. It predominantly occurs in African American men between 20-40 years of age, but can occasionally affect other races and women too. Associated musculoskeletal findings are sometimes reported. When it occurs...

PSENEN mutations underlie Dowling-Degos disease associated with acne inversa